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A-366 / 25 MG

Purity: 98% (HPLC)
Synonym: 5′-Methoxy-6′-[3-(1-pyrrolidinyl)propoxy]-spiro[cyclobutane-1,3′-[3H]indol]-2′-amine
Molecular Formula: C19H27N3O2
Molecular Weight: 329.44
SKU: MND-108265
CAS Number: 1527503-11-2
MDL number: MFCD28133403
PubChem: 329825857
Form: powder
Packing size: 25 MG  
338.80 EUR



Safety Information


Hazard Statements

H400

Precautionary Statements

P501
P273
P391

Pictograms



Properties

Signal WordWarning
Flash Point (C)Not available
Flash Point (F)Not available

 Product Description

A-366 is a chemical compound known for its role as a selective inhibitor in epigenetic research, specifically targeting a certain enzyme. It is widely used as a tool in biological studies investigating chromatin regulation.

 

Application:

Primarily employed as a selective inhibitor in epigenetic research, A-366 serves as a valuable tool for studying chromatin regulation, aiding in biological investigations focused on specific enzyme functions.

 

 

Articles:

- The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia

Publication Date: July 6, 2015

William N. Pappano ,Jun Guo ,Yupeng He,Debra Ferguson,Sujatha Jagadeeswaran,Donald J. Osterling,Wenqing Gao,Julie K. Spence,Marina Pliushchev,Ramzi F. Sweis,Fritz G. Buchanan,Michael R. Michaelides,Alexander R. Shoemaker,Chris Tse,Gary G. Chiang

https://doi.org/10.1371/journal.pone.0131716

 

- Ultraviolet radiation-A (366 nm) induced morphological and histological malformations during embryogenesis of Clarias gariepinus (Burchell, 1822)

Publication Date: Available online 20 February 2009

Usama M. Mahmoud, Imman A.A. Mekkawy, Alaa El-Din H. Sayed

https://doi.org/10.1016/j.jphotobiol.2009.02.003

 

- Abstract 5532: Discovery of A-366, a novel small molecule inhibitor that uncovers an unappreciated role for G9a/GLP in the epigenetics of leukemia

Publication Date: 2014

Jun Guo; Marina Pliushchev; Yupeng He; Debra Ferguson; Sujatha Jagadeeswaran; Andrew Petros; Chaohong Sun; Niru B. Soni; Bailin Shaw; Alla Korepanova; David Maag; Ramzi Sweis; Fritz G. Buchanan; Michael Michaelides; Alex Shoemaker; Chris Tse; Gary G. Chiang; William N. Pappano

https://doi.org/10.1158/1538-7445.AM2014-5532