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(+)-Quisqualic acid / 50mg

Purity: 99+%
Synonym: beta-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine; Quisqualate; QUISQUALIC ACID; 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine; (2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
Molecular Formula: C5H7N3O5
Molecular Weight: 189.13
SKU: MND-129491
CAS Number: 52809-07-1
MDL number: MFCD00069337
Form: Powder
Packing size: 50mg  
947.80 EUR



Safety Information


Hazard Statements

H302 + H312 + H332

Precautionary Statements

P280
P270
P261
P271
P403
P312
P264b
P302 + P352
P304 + P340
P330
P362 + P364
P501c

Pictograms



Properties

Melting Point185-187°

 Product Description

Quisqualic acid is recognized as an agonist for AMPA, kainate, and group I metabotropic glutamate receptors. It stands as one of the most potent known agonists for AMPA receptors. This compound is utilized in neuroscience to induce excitotoxicity and selectively target neurons within the brain and spinal cord. Additionally, quisqualic acid is naturally found in the seeds of Quisqualis species. Furthermore, research conducted by the USDA Agricultural Research Service has revealed the presence of quisqualic acid in the flower petals of zonal geranium (Pelargonium x hortorum), where it is responsible for inducing rigid paralysis in Japanese beetles. Quisqualic acid is believed to mimic the neurotransmitter L-glutamic acid, which plays a role in the neuromuscular junction of insects and the central nervous system of mammals.

 

 

Articles:

- Mutation-induced Quisqualic Acid and Ibotenic Acid Affinity at the Metabotropic Glutamate Receptor Subtype 4

LIGAND SELECTIVITY RESULTS FROM A SYNERGY OF SEVERAL AMINO ACID RESIDUES

Publication Date: AUGUST 2004

Mette B. Hermit, Jeremy R. Greenwood, Hans Bräuner-Osborne

https://doi.org/10.1074/jbc.M404109200

 

- Validation of Analytical Method of Quisqualic Acid for Standardization of Quisqualis indica Extract Powder (HU033)

Publication Date: online February 28, 2021

Myeong-Il Kim , Ji-Soo Yoon, Myeong-Hwan Oh, Rak-Ho Son and Sung-Hum Yeon

https://doi.org/10.3746/jkfn.2021.50.2.204

 

- α-substituted quisqualic acid analogs: New metabotropic glutamate receptor group II selective antagonists

Publication Date: Available online 23 April 1998

Alan P. Kozikowski, Darryl Steensma, Mario Varasi, Sergey Pshenichkin, Elena Surina, Jarda T. Wroblewski

https://doi.org/10.1016/S0960-894X(98)00052-3